Human T cells loaded with superparamagnetic iron oxide nanoparticles retain antigen-specific TCR functionality

Human T cells loaded with superparamagnetic iron oxide nanoparticles retain antigen-specific TCR functionality

BackgroundImmunotherapy of cancer is an emerging field with the potential to improve long-term survival. Thus far, adoptive transfer of tumor-specific T cells represents an effective treatment option for tumors of the hematological system such as lymphoma, leukemia or myeloma. However, in solid tumo...

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Bibliographic Details
Main Authors: Felix Pfister, Jan Dörrie, Niels Schaft, Vera Buchele, Harald Unterweger, Lucas R. Carnell, Patrick Schreier, Rene Stein, Markéta Kubánková, Jochen Guck, Holger Hackstein, Christoph Alexiou, Christina Janko
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Immunology
Subjects:
Adoptive T cell therapy
superparamagnetic iron oxide nanoparticles (SPIONs)
antigen-specific T cell response
targeted immune therapy
cell deformability
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1223695/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1223695/full

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