Cytosolic calcium regulates cytoplasmic accumulation of TDP-43 through Calpain-A and Importin α3

Cytosolic calcium regulates cytoplasmic accumulation of TDP-43 through Calpain-A and Importin α3

Cytoplasmic accumulation of TDP-43 in motor neurons is the most prominent pathological feature in amyotrophic lateral sclerosis (ALS). A feedback cycle between nucleocytoplasmic transport (NCT) defect and TDP-43 aggregation was shown to contribute to accumulation of TDP-43 in the cytoplasm. However,...

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Bibliographic Details
Main Authors: Jeong Hyang Park, Chang Geon Chung, Sung Soon Park, Davin Lee, Kyung Min Kim, Yeonjin Jeong, Eun Seon Kim, Jae Ho Cho, Yu-Mi Jeon, C-K James Shen, Hyung-Jun Kim, Daehee Hwang, Sung Bae Lee
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-12-01
Series:eLife
Subjects:
TDP-43
nucleocytoplasmic transport
amyotrophic lateral sclerosis
calcium
calpain
Drosophila
Online Access:https://elifesciences.org/articles/60132

Internet

https://elifesciences.org/articles/60132

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