Wnt signaling inhibition confers induced synthetic lethality to PARP inhibitors
Despite considerable efforts, therapeutic strategies targeting the Wnt pathway are still not clinically available. The pervasive role of Wnt‐βcatenin signaling for the control of stem cells during normal tissue homeostasis makes the on‐target toxicity of available therapeutic grade molecules an impo...
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| Format: | Article |
| Language: | English |
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Springer Nature
2021-04-01
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| Series: | EMBO Molecular Medicine |
| Online Access: | https://doi.org/10.15252/emmm.202114002 |