HIRA dependent H3.3 deposition is required for transcriptional reprogramming following nuclear transfer to <it>Xenopus</it> oocytes

<p>Abstract</p> <p>Background</p> <p>Nuclear reprogramming is potentially important as a route to cell replacement and drug discovery, but little is known about its mechanism. Nuclear transfer to eggs and oocytes attempts to identify the mechanism of this direct route t...

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Bibliographic Details
Main Authors: Jullien Jerome, Astrand Carolina, Szenker Emmanuelle, Garrett Nigel, Almouzni Genevieve, Gurdon John B
Format: Article
Language:English
Published: BMC 2012-10-01
Series:Epigenetics & Chromatin
Online Access:http://www.epigeneticsandchromatin.com/content/5/1/17