Nature-Inspired Hybrids (NIH) Improve Proteostasis by Activating Nrf2-Mediated Protective Pathways in Retinal Pigment Epithelial Cells

Nature-Inspired Hybrids (NIH) Improve Proteostasis by Activating Nrf2-Mediated Protective Pathways in Retinal Pigment Epithelial Cells

Antioxidant systems play key roles in many elderly diseases, including age-related macular degeneration (AMD). Oxidative stress, autophagy impairment and inflammation are well-described in AMD, especially in retinal pigment epithelial (RPE) cells. The master regulator of antioxidant defense Nrf2 has...

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Bibliographic Details
Main Authors: Ali Koskela, Federico Manai, Filippo Basagni, Mikko Liukkonen, Michela Rosini, Stefano Govoni, Massimo Dal Monte, Adrian Smedowski, Kai Kaarniranta, Marialaura Amadio
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Antioxidants
Subjects:
autophagy
age-related macular degeneration (AMD)
cytoprotection
Nrf2
pharmacological modulation
SQSTM1/p62
Online Access:https://www.mdpi.com/2076-3921/11/7/1385

Internet

https://www.mdpi.com/2076-3921/11/7/1385

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