Dynein Transmits Polarized Actomyosin Cortical Flows to Promote Centrosome Separation

The two centrosomes present at the onset of mitosis must separate in a timely and accurate fashion to ensure proper bipolar spindle assembly. The minus-end-directed motor dynein plays a pivotal role in centrosome separation, but the underlying mechanisms remain elusive, particularly regarding how dy...

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Bibliographic Details
Main Authors: Alessandro De Simone, François Nédélec, Pierre Gönczy
Format: Article
Language:English
Published: Elsevier 2016-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716300936