The Small-Molecule Wnt Inhibitor ICG-001 Efficiently Inhibits Colorectal Cancer Stemness and Metastasis by Suppressing MEIS1 Expression

The Small-Molecule Wnt Inhibitor ICG-001 Efficiently Inhibits Colorectal Cancer Stemness and Metastasis by Suppressing MEIS1 Expression

Recurrence and metastasis remain major obstacles in colorectal cancer (CRC) treatment. Recent studies suggest that a small subpopulation of cells with a self-renewal ability, called cancer stem-like cells (CSCs), promotes recurrence and metastasis in CRC. Unfortunately, no CSC inhibitor has been dem...

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Bibliographic Details
Main Authors: Jang-Hyun Choi, Tae-Young Jang, So-El Jeon, Jee-Heun Kim, Choong-Jae Lee, Hyeon-Ji Yun, Ji-Youn Jung, So-Yeon Park, Jeong-Seok Nam
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
colorectal cancer
cancer stem-like cells
metastasis
Wnt
ICG-001
MEIS1
Online Access:https://www.mdpi.com/1422-0067/22/24/13413

Internet

https://www.mdpi.com/1422-0067/22/24/13413

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