The role of SWI/SNF chromatin remodelers in the repair of DNA double strand breaks and cancer therapy

The role of SWI/SNF chromatin remodelers in the repair of DNA double strand breaks and cancer therapy

Switch/Sucrose non-fermenting (SWI/SNF) chromatin remodelers hydrolyze ATP to push and slide nucleosomes along the DNA thus modulating access to various genomic loci. These complexes are the most frequently mutated epigenetic regulators in human cancers. SWI/SNF complexes are well known for their fu...

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Bibliographic Details
Main Authors: Maria Sadek, Anand Sheth, Grant Zimmerman, Emily Hays, Renier Vélez-Cruz
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
chromatin remodelers
homologous recombination
double strand break repair
cancer therapy
DNA end resection
SWI/SNF
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.1071786/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.1071786/full

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