Systematic Mutant Analyses Elucidate General and Client-Specific Aspects of Hsp90 Function

To probe the mechanism of the Hsp90 chaperone that is required for the maturation of many signaling proteins in eukaryotes, we analyzed the effects of all individual amino acid changes in the ATPase domain on yeast growth rate. The sensitivity of a position to mutation was strongly influenced by pro...

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Bibliographic Details
Main Authors: Parul Mishra, Julia M. Flynn, Tyler N. Starr, Daniel N.A. Bolon
Format: Article
Language:English
Published: Elsevier 2016-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716303175