Research Progress and Prospects of Isocitrate Dehydrogenase Gene Mutation in Chondrosarcoma

Research Progress and Prospects of Isocitrate Dehydrogenase Gene Mutation in Chondrosarcoma

Isocitrate dehydrogenase (IDH) is the more mutation-prone human metabolic gene. In the presence of nicotinamide adenine dinucleotide phosphate (NADPH), mutant IDH can bind to α-ketoglutaric acid (α-KG) and reduce it to 2-hydroxyglutaric acid (2-HG), participating in various bio...

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Bibliographic Details
Main Author: ZHAO Jingjing, ZHANG Zhihong, ZHEN Junping
Format: Article
Language:zho
Published: Chinese General Practice Publishing House Co., Ltd 2024-04-01
Series:Zhongguo quanke yixue
Subjects:
chondrosarcoma|isocitrate dehydrogenase|mutation|tumor treatment|review
Online Access:https://www.chinagp.net/fileup/1007-9572/PDF/20230284.pdf

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