Targeting lipid metabolism as a new therapeutic strategy for inherited cardiomyopathies

Targeting lipid metabolism as a new therapeutic strategy for inherited cardiomyopathies

Inherited cardiomyopathies caused by pathological genetic variants include multiple subtypes of heart disease. Advances in next-generation sequencing (NGS) techniques have allowed for the identification of numerous genetic variants as pathological variants. However, the disease penetrance varies amo...

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Bibliographic Details
Main Authors: Karen R. Gaar-Humphreys, Alyssa van den Brink, Mark Wekking, Folkert W. Asselbergs, Frank G. van Steenbeek, Magdalena Harakalova, Jiayi Pei
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
hypertrophic cardiomyopathy
dilated cardiomyopathy
genetic variants
lipid metabolism
fatty acid oxidation
transcription factor PPARA
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2023.1114459/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2023.1114459/full

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