Targeting lipid metabolism as a new therapeutic strategy for inherited cardiomyopathies

Targeting lipid metabolism as a new therapeutic strategy for inherited cardiomyopathies

Inherited cardiomyopathies caused by pathological genetic variants include multiple subtypes of heart disease. Advances in next-generation sequencing (NGS) techniques have allowed for the identification of numerous genetic variants as pathological variants. However, the disease penetrance varies amo...

Full description

Bibliographic Details
Main Authors:	Karen R. Gaar-Humphreys, Alyssa van den Brink, Mark Wekking, Folkert W. Asselbergs, Frank G. van Steenbeek, Magdalena Harakalova, Jiayi Pei
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-01-01
Series:	Frontiers in Cardiovascular Medicine
Subjects:	hypertrophic cardiomyopathy dilated cardiomyopathy genetic variants lipid metabolism fatty acid oxidation transcription factor PPARA
Online Access:	https://www.frontiersin.org/articles/10.3389/fcvm.2023.1114459/full

Similar Items

Inherited Cardiomyopathies and the Role of Mutations in Non-coding Regions of the Genome
by: Oday F. Salman, et al.
Published: (2018-06-01)

Editorial: Molecular pathogenesis and novel treatments for inherited cardiomyopathies
by: Chun Chou, et al.
Published: (2023-09-01)

Clinical profile and echocardiographic findings of patients with cardiomyopathy at a tertiary care hospital
by: Kishor Teple, et al.
Published: (2016-01-01)

Childhood Cardiomyopathies: A Study in Tertiary Care Hospital in Upper Egypt
by: Mohamed Abd Elaal Bakeet, et al.
Published: (2016-11-01)

TCAP gene is not a common cause of cardiomyopathy in Iranian patients
by: Zahra Alaei, et al.
Published: (2023-09-01)

Recommendations for the Management of Cardiomyopathy Mutation Carriers: Evidence, Doubts, and Intentions
by: José F. Couto, et al.
Published: (2023-07-01)

Predictive Factors for Decreasing Left Ventricular Ejection Fraction and Progression to the Dilated Phase of Hypertrophic Cardiomyopathy
by: Kakeru Ishihara, et al.
Published: (2023-08-01)

Metabolite Signature in the Carriers of Pathogenic Genetic Variants for Cardiomyopathy: A Population-Based METSIM Study
by: Rowmika Ravi, et al.
Published: (2022-05-01)

Genetic Basis of Dilated Cardiomyopathy in Dogs and Its Potential as a Bidirectional Model
by: Karen R. Gaar-Humphreys, et al.
Published: (2022-06-01)

Extracellular vesicles in cardiomyopathies: A narrative review
by: A.S. Rizzuto, et al.
Published: (2024-01-01)

Pheochromocytoma/paraganglioma-associated cardiomyopathy
by: Alicja Szatko, et al.
Published: (2023-07-01)

Editorial: Cardiomyopathies: Current Treatment and Future Options
by: Stefan Peters
Published: (2020-10-01)

Editorial: Cardiovascular genetics—focus on paediatric cardiomyopathy
by: Emanuele Monda, et al.
Published: (2023-02-01)

MicroRNAs: From Junk RNA to Life Regulators and Their Role in Cardiovascular Disease
by: Federica Amodio, et al.
Published: (2021-11-01)

Pathobiology of cardiomyopathies: Experience at a Tertiary Care Center
by: Uma Nahar Saikia, et al.
Published: (2015-01-01)

Cardiomyopathies: An Overview
by: Tiziana Ciarambino, et al.
Published: (2021-07-01)

The Role of Speckle Tracking Echocardiography in the Evaluation of Common Inherited Cardiomyopathies in Children and Adolescents: A Systematic Review
by: Dan M. Dorobantu, et al.
Published: (2021-04-01)

Personalized Management of Sudden Death Risk in Primary Cardiomyopathies: From Clinical Evaluation and Multimodality Imaging to Ablation and Cardioverter-Defibrillator Implant
by: Davide Lazzeroni, et al.
Published: (2023-05-01)

MicroRNAs in Hypertrophic, Arrhythmogenic and Dilated Cardiomyopathy
by: Enrica Chiti, et al.
Published: (2021-09-01)

From Genetic Mutations to Molecular Basis of Heart Failure Treatment: An Overview of the Mechanism and Implication of the Novel Modulators for Cardiac Myosin
by: Yu-Jen Chen, et al.
Published: (2021-06-01)

Non-Cardiac Cause of Death in Selected Group Children with Cardiac Pathology: A Retrospective Single Institute Study
by: Stefana Maria Moisa, et al.
Published: (2022-03-01)

Hypertrophic Cardiomyopathy : A Practical Guide to Diagnosis and Management /
by: Adhyapak, Srilakshmi M., editor 635827, et al.
Published: (2021)

Overview of the 2023 ESC guidelines for the management of cardiomyopathies
by: Yuriy Ivaniv, et al.
Published: (2023-12-01)

Characterization of Non-Ischemic Dilated Cardiomyopathy in a Native Tanzanian Cohort: MOYO Study
by: Lulu Said Fundikira, et al.
Published: (2024-02-01)

Atrial fibrillation, anticoagulation management and risk of stroke in the Cardiomyopathy/Myocarditis registry of the EURObservational Research Programme of the European Society of Cardiology
by: Katarzyna Mizia‐Stec, et al.
Published: (2020-12-01)

Hypertrophic, Dilated, and Arrhythmogenic Cardiomyopathy: Where Are We?
by: Hamza El Hadi, et al.
Published: (2023-02-01)

The pivotal role of ECG in cardiomyopathies
by: Elisa Silvetti, et al.
Published: (2023-06-01)

Pattern of delayed myocardial enhancement: A key to differentiate ischemic and non-ischemic cardiomyopathies
by: N.H. Behairy, et al.
Published: (2014-03-01)

Apical Hypertrophic Cardiomyopathy: A Special Entity.
by: Ajay Adhikaree, et al.
Published: (2020-01-01)

Locational memory of macrovessel vascular cells is transcriptionally imprinted
by: Talitha C. F. Spanjersberg, et al.
Published: (2023-08-01)

A gradient of force generation at rest differentiates cardiomyopathy outcomes with variants of actin located at the same residue
by: Michael R. Jones, et al.
Published: (2022-12-01)

Hypertrophic Cardiomyopathy in a Latin American Center: A Single Center Observational Study
by: Juan David López-Ponce de Leon, et al.
Published: (2023-08-01)

Blood‐based biomarkers for the prediction of hypertrophic cardiomyopathy prognosis: a systematic review and meta‐analysis
by: Mark Jansen, et al.
Published: (2022-10-01)

Diagnosis and Risk Prediction of Dilated Cardiomyopathy in the Era of Big Data and Genomics
by: Arjan Sammani, et al.
Published: (2021-02-01)

Identifying Obstructive Hypertrophic Cardiomyopathy from Nonobstructive Hypertrophic Cardiomyopathy: Development and Validation of a Model Based on Electrocardiogram Features
by: Lanyan Guo, et al.
Published: (2023-08-01)

Recent Findings Related to Cardiomyopathy and Genetics
by: Takanobu Yamada, et al.
Published: (2021-11-01)

Familial risk of dilated and hypertrophic cardiomyopathy: a national family study in Sweden
by: Fabrizio Ricci, et al.
Published: (2023-02-01)

Autosomal Dominant Polycystic Kidney Patients May Be Predisposed to Various Cardiomyopathies
by: Fouad T. Chebib, et al.
Published: (2017-09-01)

Genomic Context Differs Between Human Dilated Cardiomyopathy and Hypertrophic Cardiomyopathy
by: Megan J. Puckelwartz, et al.
Published: (2021-04-01)

A complex unit for a complex disease: the HCM-Family Unit
by: Olga Vriz, et al.
Published: (2021-12-01)