Donanemab exposure and efficacy relationship using modeling in Alzheimer's disease

Donanemab exposure and efficacy relationship using modeling in Alzheimer's disease

Abstract INTRODUCTION Donanemab is an amyloid‐targeting therapy that specifically targets brain amyloid plaques. The objective of these analyses was to characterize the relationship of donanemab exposure with plasma biomarkers and clinical efficacy through modeling. METHODS Data for the analyses wer...

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Bibliographic Details
Main Authors: Ivelina Gueorguieva, Brian A. Willis, Laiyi Chua, Kay Chow, C. Steven Ernest II, Jian Wang, Sergey Shcherbinin, John R. Sims, Emmanuel Chigutsa
Format: Article
Language:English
Published: Wiley 2023-04-01
Series:Alzheimer’s & Dementia: Translational Research & Clinical Interventions
Subjects:
Alzheimer's disease
amyloid plaques
Clinical Dementia Rating‐Sum of Boxes
donanemab
integrated Alzheimer’s Disease Rating Scale
modeling
Online Access:https://doi.org/10.1002/trc2.12404

Internet

https://doi.org/10.1002/trc2.12404

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