Spermidine protects against acute kidney injury by modulating macrophage NLRP3 inflammasome activation and mitochondrial respiration in an eIF5A hypusination-related pathway

Spermidine protects against acute kidney injury by modulating macrophage NLRP3 inflammasome activation and mitochondrial respiration in an eIF5A hypusination-related pathway

Abstract Background Acute kidney injury (AKI) is still a critical problem in clinical practice, with a heavy burden for national health system around the world. It is notable that sepsis is the predominant cause of AKI for patients in the intensive care unit and the mortality remains considerably hi...

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Bibliographic Details
Main Authors: Xianzhi Li, Xiaojun Zhou, Xigao Liu, Xiaoyun Li, Xianzhou Jiang, Benkang Shi, Shuo Wang
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Molecular Medicine
Subjects:
Spermidine
Polyamine
Acute kidney injury
Macrophage
NLRP3
Online Access:https://doi.org/10.1186/s10020-022-00533-1

Internet

https://doi.org/10.1186/s10020-022-00533-1

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