Guanylyl Cyclase A/cGMP Signaling Slows Hidden, Age- and Acoustic Trauma-Induced Hearing Loss

Guanylyl Cyclase A/cGMP Signaling Slows Hidden, Age- and Acoustic Trauma-Induced Hearing Loss

In the inner ear, cyclic guanosine monophosphate (cGMP) signaling has been described as facilitating otoprotection, which was previously observed through elevated cGMP levels achieved by phosphodiesterase 5 inhibition. However, to date, the upstream guanylyl cyclase (GC) subtype eliciting cGMP produ...

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Bibliographic Details
Main Authors: Philine Marchetta, Dorit Möhrle, Philipp Eckert, Katrin Reimann, Steffen Wolter, Arianna Tolone, Isabelle Lang, Markus Wolters, Robert Feil, Jutta Engel, François Paquet-Durand, Michaela Kuhn, Marlies Knipper, Lukas Rüttiger
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Aging Neuroscience
Subjects:
inner ear
cGMP
otoprotection
guanylyl cyclase A
aging
hidden hearing loss
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2020.00083/full

Internet

https://www.frontiersin.org/article/10.3389/fnagi.2020.00083/full

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