Standardizing Patient-Derived Organoid Generation Workflow to Avoid Microbial Contamination From Colorectal Cancer Tissues

Standardizing Patient-Derived Organoid Generation Workflow to Avoid Microbial Contamination From Colorectal Cancer Tissues

The use of patient-derived organoids (PDO) as a valuable alternative to in vivo models significantly increased over the last years in cancer research. The ability of PDOs to genetically resemble tumor heterogeneity makes them a powerful tool for personalized drug screening. Despite the extensive opt...

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Bibliographic Details
Main Authors: Mattia Marinucci, Caner Ercan, Stephanie Taha-Mehlitz, Lana Fourie, Federica Panebianco, Gaia Bianco, John Gallon, Sebastian Staubli, Savas D. Soysal, Andreas Zettl, Stephan Rauthe, Jürg Vosbeck, Raoul A. Droeser, Martin Bolli, Ralph Peterli, Markus von Flüe, Charlotte K. Y. Ng, Otto Kollmar, Mairene Coto-Llerena, Salvatore Piscuoglio
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Oncology
Subjects:
patient-derived organoids
colorectal cancer
Primocin
antibiotics
microbial contamination control
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.781833/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.781833/full

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