Absence of the lectin-like domain of thrombomodulin reduces HSV-1 lethality of mice with increased microglia responses

Absence of the lectin-like domain of thrombomodulin reduces HSV-1 lethality of mice with increased microglia responses

Abstract Background Herpes simplex virus 1 (HSV-1) can induce fatal encephalitis. Cellular factors regulate the host immunity to affect the severity of HSV-1 encephalitis. Recent reports focus on the significance of thrombomodulin (TM), especially the domain 1, lectin-like domain (TM-LeD), which mod...

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Bibliographic Details
Main Authors: Meng-Shan Tsai, Li-Chiu Wang, Hua-Lin Wu, Shun-Fen Tzeng, Edward M. Conway, Sheng-Min Hsu, Shun-Hua Chen
Format: Article
Language:English
Published: BMC 2022-03-01
Series:Journal of Neuroinflammation
Subjects:
HSV-1
Encephalitis
Thrombomodulin
Lectin-like domain
Microglia
Online Access:https://doi.org/10.1186/s12974-022-02426-w

Internet

https://doi.org/10.1186/s12974-022-02426-w

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