Tetramethylpyrazine Alleviates Endothelial Glycocalyx Degradation and Promotes Glycocalyx Restoration via TLR4/NF-κB/HPSE1 Signaling Pathway During Inflammation

Tetramethylpyrazine Alleviates Endothelial Glycocalyx Degradation and Promotes Glycocalyx Restoration via TLR4/NF-κB/HPSE1 Signaling Pathway During Inflammation

Tetramethylpyrazine (TMP), a Chinese traditional herbal extraction widely used in treating cardiovascular diseases, could attenuate vascular endothelial injuries, but the underlying mechanism remains incomprehensive. Vascular glycocalyx coating on the endothelium would be damaged and caused endothel...

Full description

Bibliographic Details
Main Authors: Jin Lei, Peng Xiang, Shengmei Zeng, Le Chen, Lei Zhang, Zhiyi Yuan, Jun Zhang, Tingting Wang, Ruihong Yu, Wanping Zhang, Issa Issoufou Ibrahim, Limei Ma, Chao Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Pharmacology
Subjects:
endothelial glycocalyx
TMP
HPSE1
TLR4/NF-κB signaling pathway
LPS
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.791841/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.791841/full

Similar Items