Cellular senescence mediates the detrimental effect of prenatal dexamethasone exposure on postnatal long bone growth in mouse offspring

Cellular senescence mediates the detrimental effect of prenatal dexamethasone exposure on postnatal long bone growth in mouse offspring

Abstract Background Prenatal dexamethasone exposure (PDE) induces low birth weight and retardation of fetal bone development which are associated with lower peak bone mass in adult offspring. Here we evaluated whether and how PDE affects postnatal long bone growth in mouse offspring. Methods Pregnan...

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Bibliographic Details
Main Authors: Jianwen Su, Yu Chai, Zhiguo Ji, Yongheng Xie, Bin Yu, Xianrong Zhang
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Stem Cell Research & Therapy
Subjects:
Dexamethasone
Bone development
Bone mesenchymal stem cells
Cellular senescence
Online Access:http://link.springer.com/article/10.1186/s13287-020-01790-9

Internet

http://link.springer.com/article/10.1186/s13287-020-01790-9

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