The Role of Tryptophan Dysmetabolism and Quinolinic Acid in Depressive and Neurodegenerative Diseases

Emerging evidence suggests that neuroinflammation is involved in both depression and neurodegenerative diseases. The kynurenine pathway, generating metabolites which may play a role in pathogenesis, is one of several competing pathways of tryptophan metabolism. The present article is a narrative rev...

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Bibliographic Details
Main Authors: Knut Hestad, Jan Alexander, Helge Rootwelt, Jan O. Aaseth
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Biomolecules
Subjects:
Online Access:https://www.mdpi.com/2218-273X/12/7/998