I-κB kinase-ε deficiency improves doxorubicin-induced dilated cardiomyopathy by inhibiting the NF-κB pathway

I-κB kinase-ε deficiency improves doxorubicin-induced dilated cardiomyopathy by inhibiting the NF-κB pathway

Dilated cardiomyopathy (DCM) can lead to heart expansion and severe heart failure, but its specific pathogenesis is still elusive. In many cardiovascular diseases, I-κB kinase-ε (IKKε) has been recognized as a pro-inflammatory molecule. In this study, wild-type mice (WT, n = 14) and IKKε knockout mi...

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Bibliographic Details
Main Authors: Yafeng Liu, Yueyue Xu, Yiwei Yao, Yide Cao, Ganyi Chen, Yuchen Cai, Wen Chen, Xin Chen, Zhibing Qiu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Physiology
Subjects:
IKKε
doxorubicin
dilated cardiomyopathy
pyroptosis
connexin43
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.934899/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2022.934899/full

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