Detection of VAMP Proteolysis by Tetanus and Botulinum Neurotoxin Type B In Vivo with a Cleavage-Specific Antibody

Detection of VAMP Proteolysis by Tetanus and Botulinum Neurotoxin Type B In Vivo with a Cleavage-Specific Antibody

Tetanus and Botulinum type B neurotoxins are bacterial metalloproteases that specifically cleave the vesicle-associated membrane protein VAMP at an identical peptide bond, resulting in inhibition of neuroexocytosis. The minute amounts of these neurotoxins commonly used in experimental animals are no...

Full description

Bibliographic Details
Main Authors: Federico Fabris, Petra Šoštarić, Ivica Matak, Thomas Binz, Anna Toffan, Morena Simonato, Cesare Montecucco, Marco Pirazzini, Ornella Rossetto
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
botulinum neurotoxins
tetanus neurotoxins
vesicle-associated membrane protein VAMP
SNARE proteins
polyclonal antibodies
Online Access:https://www.mdpi.com/1422-0067/23/8/4355

Internet

https://www.mdpi.com/1422-0067/23/8/4355

Similar Items