Neurotoxicity mechanism of aconitine in HT22 cells studied by microfluidic chip-mass spectrometry

Aconitine, a common and main toxic component of Aconitum, is toxic to the central nervous system. However, the mechanism of aconitine neurotoxicity is not yet clear. In this work, we had the hypothesis that excitatory amino acids can trigger excitotoxicity as a pointcut to explore the mechanism of n...

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Bibliographic Details
Main Authors: Yingrui Zhang, Shiyu Chen, Fangfang Fan, Ning Xu, Xian-Li Meng, Yi Zhang, Jin-Ming Lin
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Journal of Pharmaceutical Analysis
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177922001204