Plasmacytoid dendritic cells are increased in cerebrospinal fluid of untreated patients during multiple sclerosis relapse
<p>Abstract</p> <p>The plasmacytoid dendritic cells (pDCs) express a high level of Toll-like receptor 9 (TLR-9), which recognizes viral DNA. Activated via TLR-9, pDCs also secrete large amounts of type I interferon which are involved either in stimulation or down regulation of immu...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2011-01-01
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| Series: | Journal of Neuroinflammation |
| Online Access: | http://www.jneuroinflammation.com/content/8/1/2 |
| _version_ | 1818113544632139776 |
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| author | Quispe-Cabanillas Juan G Oliveira Elaine C Farias Alessandro S Moraes Adriel S Pradella Fernando de Paula Rosemeire FO Brandão Carlos von Glehn Felipe Longhini Ana Abreu Cassiana Damasceno Alfredo Damasceno Benito P Balashov Konstantin E Santos Leonilda MB |
| author_facet | Quispe-Cabanillas Juan G Oliveira Elaine C Farias Alessandro S Moraes Adriel S Pradella Fernando de Paula Rosemeire FO Brandão Carlos von Glehn Felipe Longhini Ana Abreu Cassiana Damasceno Alfredo Damasceno Benito P Balashov Konstantin E Santos Leonilda MB |
| author_sort | Quispe-Cabanillas Juan G |
| collection | DOAJ |
| description | <p>Abstract</p> <p>The plasmacytoid dendritic cells (pDCs) express a high level of Toll-like receptor 9 (TLR-9), which recognizes viral DNA. Activated via TLR-9, pDCs also secrete large amounts of type I interferon which are involved either in stimulation or down regulation of immune response in multiple sclerosis (MS). In the present study, we determinate pDCs levels by flow cytometry in Cerebrospinal Fluid (CSF) and Peripheral Blood from MS patients in relapsing and in remitting phases of the disease, comparing with other non-inflammatory diseases (OND). We provide evidence that MS patients in relapse without any treatment have a significantly (p < 0.01) higher percentage of pDCs in CSF than do patients in remission or those with OND. No change in the percentage of pDCs was observed in the peripheral blood of any of these patients. The increase of pDCs in central nervous system during relapse may be explained either by a virus infection or a down regulatory process.</p> |
| first_indexed | 2024-12-11T03:36:31Z |
| format | Article |
| id | doaj.art-47170d2f6c534f678e10e26bae1f6e9e |
| institution | Directory Open Access Journal |
| issn | 1742-2094 |
| language | English |
| last_indexed | 2024-12-11T03:36:31Z |
| publishDate | 2011-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Neuroinflammation |
| spelling | doaj.art-47170d2f6c534f678e10e26bae1f6e9e2022-12-22T01:22:14ZengBMCJournal of Neuroinflammation1742-20942011-01-0181210.1186/1742-2094-8-2Plasmacytoid dendritic cells are increased in cerebrospinal fluid of untreated patients during multiple sclerosis relapseQuispe-Cabanillas Juan GOliveira Elaine CFarias Alessandro SMoraes Adriel SPradella Fernandode Paula Rosemeire FOBrandão Carlosvon Glehn FelipeLonghini AnaAbreu CassianaDamasceno AlfredoDamasceno Benito PBalashov Konstantin ESantos Leonilda MB<p>Abstract</p> <p>The plasmacytoid dendritic cells (pDCs) express a high level of Toll-like receptor 9 (TLR-9), which recognizes viral DNA. Activated via TLR-9, pDCs also secrete large amounts of type I interferon which are involved either in stimulation or down regulation of immune response in multiple sclerosis (MS). In the present study, we determinate pDCs levels by flow cytometry in Cerebrospinal Fluid (CSF) and Peripheral Blood from MS patients in relapsing and in remitting phases of the disease, comparing with other non-inflammatory diseases (OND). We provide evidence that MS patients in relapse without any treatment have a significantly (p < 0.01) higher percentage of pDCs in CSF than do patients in remission or those with OND. No change in the percentage of pDCs was observed in the peripheral blood of any of these patients. The increase of pDCs in central nervous system during relapse may be explained either by a virus infection or a down regulatory process.</p>http://www.jneuroinflammation.com/content/8/1/2 |
| spellingShingle | Quispe-Cabanillas Juan G Oliveira Elaine C Farias Alessandro S Moraes Adriel S Pradella Fernando de Paula Rosemeire FO Brandão Carlos von Glehn Felipe Longhini Ana Abreu Cassiana Damasceno Alfredo Damasceno Benito P Balashov Konstantin E Santos Leonilda MB Plasmacytoid dendritic cells are increased in cerebrospinal fluid of untreated patients during multiple sclerosis relapse Journal of Neuroinflammation |
| title | Plasmacytoid dendritic cells are increased in cerebrospinal fluid of untreated patients during multiple sclerosis relapse |
| title_full | Plasmacytoid dendritic cells are increased in cerebrospinal fluid of untreated patients during multiple sclerosis relapse |
| title_fullStr | Plasmacytoid dendritic cells are increased in cerebrospinal fluid of untreated patients during multiple sclerosis relapse |
| title_full_unstemmed | Plasmacytoid dendritic cells are increased in cerebrospinal fluid of untreated patients during multiple sclerosis relapse |
| title_short | Plasmacytoid dendritic cells are increased in cerebrospinal fluid of untreated patients during multiple sclerosis relapse |
| title_sort | plasmacytoid dendritic cells are increased in cerebrospinal fluid of untreated patients during multiple sclerosis relapse |
| url | http://www.jneuroinflammation.com/content/8/1/2 |
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