Ginsenoside CK ameliorates tumor growth in lung cancer mice via inhibiting EGFR

Ginsenoside CK ameliorates tumor growth in lung cancer mice via inhibiting EGFR

In this work, ginsenoside CK was confirmed as an EGFR tyrosine kinase inhibitor, with an IC50 value of 32.58 ± 0.09 μM. Molecular docking showed that ginsenoside CK could fit into EGFR binding pocket, thereby acting as a ligand for EGFR. Ginsenoside CK inhibited proliferation of A549 cells as well a...

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Bibliographic Details
Main Authors: Yuan Liang, Qing Wang, Dianwen Zhang, Yiyao Gong, Qiuyan Jiang, Cong Ma, Libo Si, Tiehua Zhang, Jie Zhang, Zheng Ma
Format: Article
Language:English
Published: Elsevier 2024-10-01
Series:Journal of Functional Foods
Subjects:
Epidermal growth factor receptor
Tyrosine kinase inhibitor
Anti-lung cancer effect
Ginsenoside CK
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464624004481

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http://www.sciencedirect.com/science/article/pii/S1756464624004481

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