A Non-Systemic Phosphodiesterase-5 Inhibitor Suppresses Colon Proliferation in Mice

A Non-Systemic Phosphodiesterase-5 Inhibitor Suppresses Colon Proliferation in Mice

Phosphodiesterase-5 inhibitors (PDE5i) are under investigation for repurposing for colon cancer prevention. A drawback to conventional PDE5i are their side-effects and drug–drug interactions. We designed an analog of the prototypical PDE5i sildenafil by replacing the methyl group on the piperazine r...

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Bibliographic Details
Main Authors: Avelina Lee, Iryna Lebedyeva, Wenbo Zhi, Vani Senthil, Herjot Cheema, Michael W. Brands, Weston Bush, Nevin A. Lambert, Madeline Snipes, Darren D. Browning
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
Subjects:
phosphodiesterase inhibitor
pharmacokinetics
intestines
colon neoplasms
cyclic guanosine monophosphate
Online Access:https://www.mdpi.com/1422-0067/24/11/9397

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https://www.mdpi.com/1422-0067/24/11/9397

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