Structural basis for the neurotropic AAV9 and the engineered AAVPHP.eB recognition with cellular receptors

Structural basis for the neurotropic AAV9 and the engineered AAVPHP.eB recognition with cellular receptors

Clade F adeno-associated virus (AAV) 9 has been utilized as therapeutic gene delivery vector, and it is capable of crossing blood brain barrier (BBB). Recently, an AAV9-based engineering serotype AAVPHP.eB with enhanced BBB crossing ability further expanded clade F AAVs’ usages in the murine central...

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Bibliographic Details
Main Authors: Guangxue Xu, Ran Zhang, Huapeng Li, Kaixin Yin, Xinyi Ma, Zhiyong Lou
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
AAV9
AAVPHP.eB
AAVR
LY6A
cryo-EM
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050122000742

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http://www.sciencedirect.com/science/article/pii/S2329050122000742

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