Acetate Promotes a Differential Energy Metabolic Response in Human HCT 116 and COLO 205 Colon Cancer Cells Impacting Cancer Cell Growth and Invasiveness

Acetate Promotes a Differential Energy Metabolic Response in Human HCT 116 and COLO 205 Colon Cancer Cells Impacting Cancer Cell Growth and Invasiveness

Under dysbiosis, a gut metabolic disorder, short-chain carboxylic acids (SCCAs) are secreted to the lumen, affecting colorectal cancer (CRC) development. Butyrate and propionate act as CRC growth inhibitors, but they might also serve as carbon source. In turn, the roles of acetate as metabolic fuel...

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Bibliographic Details
Main Authors: Sara Rodríguez-Enríquez, Diana Xochiquetzal Robledo-Cadena, Juan Carlos Gallardo-Pérez, Silvia Cecilia Pacheco-Velázquez, Citlali Vázquez, Emma Saavedra, Jorge Luis Vargas-Navarro, Betsy Alejandra Blanco-Carpintero, Álvaro Marín-Hernández, Ricardo Jasso-Chávez, Rusely Encalada, Luz Ruiz-Godoy, José Luis Aguilar-Ponce, Rafael Moreno-Sánchez
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Oncology
Subjects:
acetate thiokinase
cancer biomarker
colon cancer
acetylation
oxidative phoshorylation
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.697408/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.697408/full

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