NSG Mice Provide a Better Spontaneous Model of Breast Cancer Metastasis than Athymic (Nude) Mice.
Metastasis is the most common cause of mortality in breast cancer patients worldwide. To identify improved mouse models for breast cancer growth and spontaneous metastasis, we examined growth and metastasis of both estrogen receptor positive (T47D) and negative (MDA-MB-231, SUM1315, and CN34BrM) hum...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5035017?pdf=render |
| _version_ | 1818244955494154240 |
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| author | Madhavi Puchalapalli Xianke Zeng Liang Mu Aubree Anderson Laura Hix Glickman Ming Zhang Megan R Sayyad Sierra Mosticone Wangensteen Charles V Clevenger Jennifer E Koblinski |
| author_facet | Madhavi Puchalapalli Xianke Zeng Liang Mu Aubree Anderson Laura Hix Glickman Ming Zhang Megan R Sayyad Sierra Mosticone Wangensteen Charles V Clevenger Jennifer E Koblinski |
| author_sort | Madhavi Puchalapalli |
| collection | DOAJ |
| description | Metastasis is the most common cause of mortality in breast cancer patients worldwide. To identify improved mouse models for breast cancer growth and spontaneous metastasis, we examined growth and metastasis of both estrogen receptor positive (T47D) and negative (MDA-MB-231, SUM1315, and CN34BrM) human breast cancer cells in nude and NSG mice. Both primary tumor growth and spontaneous metastases were increased in NSG mice compared to nude mice. In addition, a pattern of metastasis similar to that observed in human breast cancer patients (metastases to the lungs, liver, bones, brain, and lymph nodes) was found in NSG mice. Furthermore, there was an increase in the metastatic burden in NSG compared to nude mice that were injected with MDA-MB-231 breast cancer cells in an intracardiac experimental metastasis model. This data demonstrates that NSG mice provide a better model for studying human breast cancer metastasis compared to the current nude mouse model. |
| first_indexed | 2024-12-12T14:25:14Z |
| format | Article |
| id | doaj.art-471a1724202d49e7a1e80f534a0c28cc |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T14:25:14Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-471a1724202d49e7a1e80f534a0c28cc2022-12-22T00:21:42ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01119e016352110.1371/journal.pone.0163521NSG Mice Provide a Better Spontaneous Model of Breast Cancer Metastasis than Athymic (Nude) Mice.Madhavi PuchalapalliXianke ZengLiang MuAubree AndersonLaura Hix GlickmanMing ZhangMegan R SayyadSierra Mosticone WangensteenCharles V ClevengerJennifer E KoblinskiMetastasis is the most common cause of mortality in breast cancer patients worldwide. To identify improved mouse models for breast cancer growth and spontaneous metastasis, we examined growth and metastasis of both estrogen receptor positive (T47D) and negative (MDA-MB-231, SUM1315, and CN34BrM) human breast cancer cells in nude and NSG mice. Both primary tumor growth and spontaneous metastases were increased in NSG mice compared to nude mice. In addition, a pattern of metastasis similar to that observed in human breast cancer patients (metastases to the lungs, liver, bones, brain, and lymph nodes) was found in NSG mice. Furthermore, there was an increase in the metastatic burden in NSG compared to nude mice that were injected with MDA-MB-231 breast cancer cells in an intracardiac experimental metastasis model. This data demonstrates that NSG mice provide a better model for studying human breast cancer metastasis compared to the current nude mouse model.http://europepmc.org/articles/PMC5035017?pdf=render |
| spellingShingle | Madhavi Puchalapalli Xianke Zeng Liang Mu Aubree Anderson Laura Hix Glickman Ming Zhang Megan R Sayyad Sierra Mosticone Wangensteen Charles V Clevenger Jennifer E Koblinski NSG Mice Provide a Better Spontaneous Model of Breast Cancer Metastasis than Athymic (Nude) Mice. PLoS ONE |
| title | NSG Mice Provide a Better Spontaneous Model of Breast Cancer Metastasis than Athymic (Nude) Mice. |
| title_full | NSG Mice Provide a Better Spontaneous Model of Breast Cancer Metastasis than Athymic (Nude) Mice. |
| title_fullStr | NSG Mice Provide a Better Spontaneous Model of Breast Cancer Metastasis than Athymic (Nude) Mice. |
| title_full_unstemmed | NSG Mice Provide a Better Spontaneous Model of Breast Cancer Metastasis than Athymic (Nude) Mice. |
| title_short | NSG Mice Provide a Better Spontaneous Model of Breast Cancer Metastasis than Athymic (Nude) Mice. |
| title_sort | nsg mice provide a better spontaneous model of breast cancer metastasis than athymic nude mice |
| url | http://europepmc.org/articles/PMC5035017?pdf=render |
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