Huntington’s disease age at motor onset is modified by the tandem hexamer repeat in TCERG1

Huntington’s disease age at motor onset is modified by the tandem hexamer repeat in TCERG1

Abstract Huntington’s disease is caused by an expanded CAG tract in HTT. The length of the CAG tract accounts for over half the variance in age at onset of disease, and is influenced by other genetic factors, mostly implicating the DNA maintenance machinery. We examined a single nucleotide variant,...

Full description

Bibliographic Details
Main Authors: Sergey V. Lobanov, Branduff McAllister, Mia McDade-Kumar, G. Bernhard Landwehrmeyer, Michael Orth, Anne E. Rosser, REGISTRY Investigators of the European Huntington’s disease network, Jane S. Paulsen, PREDICT-HD Investigators of the Huntington Study Group, Jong-Min Lee, Marcy E. MacDonald, James F. Gusella, Jeffrey D. Long, Mina Ryten, Nigel M. Williams, Peter Holmans, Thomas H. Massey, Lesley Jones
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:npj Genomic Medicine
Online Access:https://doi.org/10.1038/s41525-022-00317-w

Internet

https://doi.org/10.1038/s41525-022-00317-w

Similar Items