Combined action of albumin and heparin regulates lipoprotein lipase oligomerization, stability, and ligand interactions.

Combined action of albumin and heparin regulates lipoprotein lipase oligomerization, stability, and ligand interactions.

Lipoprotein lipase (LPL), a crucial enzyme in the intravascular hydrolysis of triglyceride-rich lipoproteins, is a potential drug target for the treatment of hypertriglyceridemia. The activity and stability of LPL are influenced by a complex ligand network. Previous studies performed in dilute solut...

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Bibliographic Details
Main Authors: Robert Risti, Kathryn H Gunn, Kristofer Hiis-Hommuk, Natjan-Naatan Seeba, Hamed Karimi, Ly Villo, Marko Vendelin, Saskia B Neher, Aivar Lõokene
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0283358

Internet

https://doi.org/10.1371/journal.pone.0283358

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