Evaluation of the effect of cell freshness on pyrogen detection using a serum-free monocyte-activation test.

Evaluation of the effect of cell freshness on pyrogen detection using a serum-free monocyte-activation test.

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Pyrogens cause shock symptoms when released into the bloodstream. They are classified into two main categories: endotoxins (lipopolysaccharides [LPS]) and non-endotoxin pyrogens. The monocyte activation test (MAT) is an in vitro assay to detect pyrogens in human monocytes. Cells were incubated in th...

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Bibliographic Details
Main Authors: Katsuhiko Hayashi, Mizuki Sano, Toshie Kanayasu-Toyoda, Yuji Morita, Teruhide Yamaguchi, Kenji Ohya, Yutaka Kikuchi, Ken-Ichi Izutsu, Yukiko Hara-Kudo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0316203

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https://doi.org/10.1371/journal.pone.0316203

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