Systematic evaluation of B-cell clonal family inference approaches

Systematic evaluation of B-cell clonal family inference approaches

Abstract The reconstruction of clonal families (CFs) in B-cell receptor (BCR) repertoire analysis is a crucial step to understand the adaptive immune system and how it responds to antigens. The BCR repertoire of an individual is formed throughout life and is diverse due to several factors such as ge...

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Bibliographic Details
Main Authors: Daria Balashova, Barbera D. C. van Schaik, Maria Stratigopoulou, Jeroen E. J. Guikema, Tom G. Caniels, Mathieu Claireaux, Marit J. van Gils, Anne Musters, Dornatien C. Anang, Niek de Vries, Victor Greiff, Antoine H. C. van Kampen
Format: Article
Language:English
Published: BMC 2024-02-01
Series:BMC Immunology
Subjects:
B-cell receptor repertoire
B-cell clonal family partitioning
AIRR-seq data
AIRR-seq data simulation
B-cell shared clonal families
Online Access:https://doi.org/10.1186/s12865-024-00600-8

Internet

https://doi.org/10.1186/s12865-024-00600-8

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