A major locus confers triclabendazole resistance in Fasciola hepatica and shows dominant inheritance.

Fasciola hepatica infection is responsible for substantial economic losses in livestock worldwide and poses a threat to human health in endemic areas. The mainstay of control in livestock and the only drug licenced for use in humans is triclabendazole (TCBZ). TCBZ resistance has been reported on eve...

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Bibliographic Details
Main Authors: Nicola J Beesley, Krystyna Cwiklinski, Katherine Allen, Rebecca C Hoyle, Terry W Spithill, E James La Course, Diana J L Williams, Steve Paterson, Jane E Hodgkinson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1011081