A SARS-CoV-2 variant elicits an antibody response with a shifted immunodominance hierarchy.

A SARS-CoV-2 variant elicits an antibody response with a shifted immunodominance hierarchy.

Many SARS-CoV-2 variants have mutations at key sites targeted by antibodies. However, it is unknown if antibodies elicited by infection with these variants target the same or different regions of the viral spike as antibodies elicited by earlier viral isolates. Here we compare the specificities of p...

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Bibliographic Details
Main Authors: Allison J Greaney, Tyler N Starr, Rachel T Eguia, Andrea N Loes, Khadija Khan, Farina Karim, Sandile Cele, John E Bowen, Jennifer K Logue, Davide Corti, David Veesler, Helen Y Chu, Alex Sigal, Jesse D Bloom
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-02-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1010248

Internet

https://doi.org/10.1371/journal.ppat.1010248

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