LRRK2 G2019S Promotes Colon Cancer Potentially via LRRK2–GSDMD Axis-Mediated Gut Inflammation

LRRK2 G2019S Promotes Colon Cancer Potentially via LRRK2–GSDMD Axis-Mediated Gut Inflammation

Leucine-rich repeat kinase 2 (LRRK2) is a serine–threonine protein kinase belonging to the ROCO protein family. Within the kinase domain of LRRK2, a point mutation known as LRRK2 G2019S has emerged as the most prevalent variant associated with Parkinson’s disease. Recent clinical studies have indica...

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Bibliographic Details
Main Authors: Yuhang Wang, Joyce Z. Gao, Taylor Sakaguchi, Thorsten Maretzky, Prajwal Gurung, Nandakumar S. Narayanan, Sarah Short, Yiqin Xiong, Zizhen Kang
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Cells
Subjects:
LRRK2 G2019S
colitis
colon cancer
inflammation
Online Access:https://www.mdpi.com/2073-4409/13/7/565

Internet

https://www.mdpi.com/2073-4409/13/7/565

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