LRRK2 G2019S Promotes Colon Cancer Potentially via LRRK2–GSDMD Axis-Mediated Gut Inflammation
Leucine-rich repeat kinase 2 (LRRK2) is a serine–threonine protein kinase belonging to the ROCO protein family. Within the kinase domain of LRRK2, a point mutation known as LRRK2 G2019S has emerged as the most prevalent variant associated with Parkinson’s disease. Recent clinical studies have indica...
Main Authors: | Yuhang Wang, Joyce Z. Gao, Taylor Sakaguchi, Thorsten Maretzky, Prajwal Gurung, Nandakumar S. Narayanan, Sarah Short, Yiqin Xiong, Zizhen Kang |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2024-03-01
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Series: | Cells |
Subjects: | |
Online Access: | https://www.mdpi.com/2073-4409/13/7/565 |
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