Genomic and Molecular Identification of Genes Contributing to the Caspofungin Paradoxical Effect in Aspergillus fumigatus

Genomic and Molecular Identification of Genes Contributing to the Caspofungin Paradoxical Effect in Aspergillus fumigatus

ABSTRACT Aspergillus fumigatus is a deadly opportunistic fungal pathogen responsible for ~100,000 annual deaths. Azoles are the first line antifungal agent used against A. fumigatus, but azole resistance has rapidly evolved making treatment challenging. Caspofungin is an important second-line therap...

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Bibliographic Details
Main Authors: Shu Zhao, Adela Martin-Vicente, Ana Cristina Colabardini, Lilian Pereira Silva, David C. Rinker, Jarrod R. Fortwendel, Gustavo Henrique Goldman, John G. Gibbons
Format: Article
Language:English
Published: American Society for Microbiology 2022-10-01
Series:Microbiology Spectrum
Subjects:
Aspergillus fumigatus
CRISPR
echinocandin
GWA
genomics
mycology
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00519-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.00519-22

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