TNF-α promotes α-synuclein propagation through stimulation of senescence-associated lysosomal exocytosis

TNF-α promotes α-synuclein propagation through stimulation of senescence-associated lysosomal exocytosis

Abstract Cell-to-cell propagation of α-synuclein is thought to be the underlying mechanism of Parkinson’s disease progression. Recent evidence suggests that inflammation plays an important role in the propagation of protein aggregates. However, the mechanism by which inflammation regulates the propa...

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Main Authors: Eun-Jin Bae, Minsun Choi, Jeong Tae Kim, Dong-Kyu Kim, Min Kyo Jung, Changyoun Kim, Tae-Kyung Kim, Jun Sung Lee, Byung Chul Jung, Soo Jean Shin, Ka Hyun Rhee, Seung-Jae Lee
Format: Article
Language:English
Published: Nature Publishing Group 2022-07-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-022-00789-x

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https://doi.org/10.1038/s12276-022-00789-x

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