Whole-Tissue Deconvolution and scRNAseq Analysis Identify Altered Endometrial Cellular Compositions and Functionality Associated With Endometriosis

Whole-Tissue Deconvolution and scRNAseq Analysis Identify Altered Endometrial Cellular Compositions and Functionality Associated With Endometriosis

The uterine lining (endometrium) exhibits a pro-inflammatory phenotype in women with endometriosis, resulting in pain, infertility, and poor pregnancy outcomes. The full complement of cell types contributing to this phenotype has yet to be identified, as most studies have focused on bulk tissue or s...

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Bibliographic Details
Main Authors: Daniel G. Bunis, Wanxin Wang, Júlia Vallvé-Juanico, Sahar Houshdaran, Sushmita Sen, Isam Ben Soltane, Idit Kosti, Kim Chi Vo, Juan C. Irwin, Linda C. Giudice, Marina Sirota
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Immunology
Subjects:
endometriosis
deconvolution
bulk tissue transcriptomics
single-cell analysis
eutopic endometrium
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.788315/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.788315/full

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