CNOT7 depletion reverses natural killer cell resistance by modulating the tumor immune microenvironment of hepatocellular carcinoma

CNOT7 depletion reverses natural killer cell resistance by modulating the tumor immune microenvironment of hepatocellular carcinoma

A major obstacle to effective cancer immunotherapy is the tumor immune microenvironment. Natural killer (NK) cell resistance has been suggested as a primary cause of poor prognosis in hepatocellular carcinoma (HCC), which seemingly correlates with CNOT7 overexpression. CNOT7, a cytoplasmic mRNA dead...

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Bibliographic Details
Main Authors: Chongren Ren, Xiaojing Ren, Dujuan Cao, Haichao Zhao, Zhensheng Zhai, Huiyu Li, Yanjun Li, Xifeng Fu, Jiefeng He, Haoliang Zhao
Format: Article
Language:English
Published: Wiley 2020-05-01
Series:FEBS Open Bio
Subjects:
CNOT7
hepatocellular carcinoma
HepG2
STAT1
TGF‐β1
Online Access:https://doi.org/10.1002/2211-5463.12836

Internet

https://doi.org/10.1002/2211-5463.12836

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