Quantification of Acipimox in Plasma and Tissues by LC–MS/MS: Application to Pharmacokinetic Comparison between Normoxia and Hypoxia

Quantification of Acipimox in Plasma and Tissues by LC–MS/MS: Application to Pharmacokinetic Comparison between Normoxia and Hypoxia

This study aimed to evaluate the pharmacokinetics of acipimox in rats under simulated high altitude hypoxia conditions. A sensitive and reliable LC–MS/MS method has been established for the quantitation of acipimox in rat plasma and tissue homogenate and validated according to the guidelines of the...

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Bibliographic Details
Main Authors: Xin Shen, Gaofu Li, Libin Wang, Huijin Yu, Lei Zhou, Huifang Deng, Ningning Wang, Chengcai Lai, Wei Zhou, Yue Gao
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Molecules
Subjects:
LC–MS/MS
hypoxia
acipimox
pharmacokinetics
Online Access:https://www.mdpi.com/1420-3049/27/19/6413

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https://www.mdpi.com/1420-3049/27/19/6413

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