Localization of the cannabinoid CB1 receptor and the 2-AG synthesizing (DAGLα) and degrading (MAGL, FAAH) enzymes in cells expressing the Ca2+-binding proteins calbindin, calretinin and parvalbumin in the adult rat hippocampus

Localization of the cannabinoid CB1 receptor and the 2-AG synthesizing (DAGLα) and degrading (MAGL, FAAH) enzymes in cells expressing the Ca2+-binding proteins calbindin, calretinin and parvalbumin in the adult rat hippocampus

The retrograde suppression of the synaptic transmission by the endocannabinoid sn-2-arachidonoylglycerol (2-AG) is mediated by the cannabinoid CB1 receptors and requires the elevation of intracellular Ca2+ and the activation of specific 2-AG synthesizing (i.e. DAGLα) enzymes. However, the anatomical...

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Bibliographic Details
Main Authors: Patricia eRivera, Sergio eArrabal, Manuel eCifuentes, Jesús M. Grondona, Margarita ePérez-Martín, Leticia eRubio, Antonio eVargas Fuentes, Antonia eSerrano, Francisco Javier ePavon, Juan eSuarez, Fernando eRodríguez de Fonseca
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Neuroanatomy
Subjects:
Hippocampus
Immunohistochemistry
Cannabinoid receptor
confocal microscopy
rat
2-Arachidonoylglycerol
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnana.2014.00056/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnana.2014.00056/full

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