Influence of Nodal signalling on pluripotency factor expression, tumour cell proliferation and cisplatin-sensitivity in testicular germ cell tumours

Influence of Nodal signalling on pluripotency factor expression, tumour cell proliferation and cisplatin-sensitivity in testicular germ cell tumours

Abstract Background Testicular germ cell tumours (TGCTs) are characterised by an overall high cisplatin-sensitivity which has been linked to their continued expression of pluripotency factors. Recently, the Nodal signalling pathway has been implicated in the regulation of pluripotency factor express...

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Bibliographic Details
Main Authors: K. Harpelunde Poulsen, J. E. Nielsen, B. Grønkær Toft, U. N. Joensen, L. J. Rasmussen, M. Blomberg Jensen, R. T. Mitchell, A. Juul, E. Rajpert-De Meyts, A. Jørgensen
Format: Article
Language:English
Published: BMC 2020-04-01
Series:BMC Cancer
Subjects:
Nodal and Activin signalling
Expression of pluripotency factors
GCNIS
Testicular cancer
Cisplatin-sensitivity
Online Access:http://link.springer.com/article/10.1186/s12885-020-06820-6

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http://link.springer.com/article/10.1186/s12885-020-06820-6

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