Chromone-based monoamine oxidase B inhibitor with potential iron-chelating activity for the treatment of Alzheimer’s disease
Based on the multitarget-directed ligands (MTDLs) strategy, a series of chromone-hydroxypyridinone hybrids were designed, synthesised, and evaluated as potential multimodal anti-AD ligands. Prospective iron-chelating effects and favourable monoamine oxidase B (MAO-B) inhibitory activities were obser...
| Auteurs principaux: | , , , , , , , , , |
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| Format: | Article |
| Langue: | English |
| Publié: |
Taylor & Francis Group
2023-12-01
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| Collection: | Journal of Enzyme Inhibition and Medicinal Chemistry |
| Sujets: | |
| Accès en ligne: | https://www.tandfonline.com/doi/10.1080/14756366.2022.2134358 |