E2F2 directly regulates the STAT1 and PI3K/AKT/NF-κB pathways to exacerbate the inflammatory phenotype in rheumatoid arthritis synovial fibroblasts and mouse embryonic fibroblasts

E2F2 directly regulates the STAT1 and PI3K/AKT/NF-κB pathways to exacerbate the inflammatory phenotype in rheumatoid arthritis synovial fibroblasts and mouse embryonic fibroblasts

Abstract Background Expression of E2F transcription factor 2 (E2F2), a transcription factor related to the cell cycle, is abnormally high in rheumatoid arthritis synovial fibroblasts (RASFs). Deregulated expression of E2F2 leads to abnormal production of proinflammatory cytokines, such as interleuki...

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Bibliographic Details
Main Authors: Shiguan Wang, Lin Wang, Changshun Wu, Shui Sun, Ji-hong Pan
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Arthritis Research & Therapy
Subjects:
Cytokine
Inflammation
Rheumatoid arthritis
Synovial fibroblast
E2F2
Online Access:http://link.springer.com/article/10.1186/s13075-018-1713-x

Internet

http://link.springer.com/article/10.1186/s13075-018-1713-x

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