Cardiomyocyte-specific expression of lamin a improves cardiac function in Lmna-/- mice.

Cardiomyocyte-specific expression of lamin a improves cardiac function in Lmna-/- mice.

Lmna(-/-) mice display multiple tissue defects and die by 6-8 weeks of age reportedly from dilated cardiomyopathy with associated conduction defects. We sought to determine whether restoration of lamin A in cardiomyocytes improves cardiac function and extends the survival of Lmna(-/-) mice. We obser...

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Bibliographic Details
Main Authors: Richard L Frock, Steven C Chen, Dao-Fu Da, Ellie Frett, Carmen Lau, Christina Brown, Diana N Pak, Yuexia Wang, Antoine Muchir, Howard J Worman, Luis F Santana, Warren C Ladiges, Peter S Rabinovitch, Brian K Kennedy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3419749?pdf=render

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http://europepmc.org/articles/PMC3419749?pdf=render

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