Validation of Model-Based Melt Viscosity in Hot-Melt Extrusion Numerical Simulation

Validation of Model-Based Melt Viscosity in Hot-Melt Extrusion Numerical Simulation

A validation for the use of model-based melt viscosity in hot-melt extrusion numerical simulations was presented. Here, the melt viscosity of an amorphous solid dispersion (ASD) was calculated by using its glass transition temperature (Tg) and the rheological flow profile of the pure polymeric matri...

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Bibliographic Details
Main Authors: Esther S. Bochmann, Andreas Gryczke, Karl G. Wagner
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Pharmaceutics
Subjects:
hot-melt extrusion
melt rheology
glass transition temperature
amorphous solid dispersion
simulation
prediction model
Online Access:http://www.mdpi.com/1999-4923/10/3/132

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http://www.mdpi.com/1999-4923/10/3/132

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