Optimization of eIF4E-Binding Peptide Pep8 to Disrupt the RBM38-eIF4E Complex for Induction of p53 and Tumor Suppression

Optimization of eIF4E-Binding Peptide Pep8 to Disrupt the RBM38-eIF4E Complex for Induction of p53 and Tumor Suppression

Interaction of RNA-binding protein RBM38 with eIF4E on p53 mRNA is known to suppress p53 mRNA translation, which can be disrupted by an 8-amino acid peptide (Pep8-YPYAASPA) derived from RBM38, leading to induction of p53 and tumor suppression. Here, we rationally designed multiple Pep8 derivatives a...

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Bibliographic Details
Main Authors: Christopher A. Lucchesi, Jin Zhang, Demitria M. Vasilatis, Elizabeth Yip, Xinbin Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Oncology
Subjects:
eIF4E
RBM38
p53
eIF4E-binding peptide
peptide
radiotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.893062/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.893062/full

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