Dyskerin Downregulation Can Induce ER Stress and Promote Autophagy via AKT-mTOR Signaling Deregulation

Dyskerin Downregulation Can Induce ER Stress and Promote Autophagy via AKT-mTOR Signaling Deregulation

Dyskerin is an evolutionarily conserved nucleolar protein implicated in a wide range of fundamental biological roles, including telomere maintenance and ribosome biogenesis. Germline mutations of <i>DKC1</i>, the human gene encoding dyskerin, cause the hereditary disorders known as X-lin...

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Bibliographic Details
Main Authors: Daniela Maiello, Marianna Varone, Rosario Vicidomini, Valentina Belli, Marina De Rosa, Paola Dama, Maria Furia, Mimmo Turano
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Biomedicines
Subjects:
dyskeratosis congenita
DKC1
autophagic flux
UPR
LC3 puncta
Online Access:https://www.mdpi.com/2227-9059/10/5/1092

Internet

https://www.mdpi.com/2227-9059/10/5/1092

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